化合物 T12720
普啉索旦(Prinoxodan)
CAS: 111786-07-3
化学式: C13H14N4O2
| 中文名 | 普啉索旦 |
| 英文名 | Prinoxodan |
| 别名 | 普啉索旦 化合物 T12720 |
| 英文别名 | RGW2938 Prinoxodan Prinoxodan (RGW2938) 2(1H)-Quinazolinone, 3,4-dihydro-3-methyl-6-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl)- |
| CAS | 111786-07-3 |
| 化学式 | C13H14N4O2 |
| 分子量 | 258.28 |
| 密度 | 1.47±0.1 g/cm3(Predicted) |
| 熔点 | >250 °C |
| 酸度系数 | 13.58±0.40(Predicted) |
| 存储条件 | Room Temprature |
| 体外研究 | Prinoxodan (RG W-2938) is an orally effective positive inotropic/vasodilator agent. Prinoxodan is a new nonglycoside, noncatecholamine cardiotonic/vasodilator agent is examined in vitro in isolated guinea pig hearts; in the latter, Prinoxodan 5 nmol-5 μmol increases contractility in a dose-related fashion. |
| 体内研究 | Prinoxodan (RG W-2938) is a new nonglycoside, noncatecholamine cardiotonic/vasodilator agent is examined in vivo in anesthetized and conscious dogs. Prinoxodan 30-300 μg/kg administered intravenously (i.v.) to anesthetized dogs increases contractile force while decreasing arterial pressure and total peripheral resistance (TPR) in a dose-related manner. Heart rate (HR) is only slightly increased, and aortic flow is not appreciably altered. A single oral dose of Prinoxodan 0.3 mg/kg administered to conscious chronically instrumented dogs produces a marked and sustained increase in contractility 15-240 min after treatment while only slightly increasing HR. The effects of Prinoxodan 30-300 μg/kg, i.v. are studied in a mecamylamine-propranolol-induced model of heart failure. Prinoxodan effectively reverses the drug-induced heart failure by increasing myocardial contractility and decreasing arterial pressure while only slightly affecting HR. |
供应商列表
现货供应
产品名: Prinoxodan 去供应商网站查看 询盘CAS: 111786-07-3
产地: 上海
规格: P910818
价格: 1mg-4680
库存: 7天内发货
电话: 13816333479/17821173903
手机: 13816333479/17821173903
电子邮件: wangrui@macklin.cn
QQ: 2885703204/288570320
微信: 19863730987/17821173903
现货供应
产品名: Prinoxodan 去供应商网站查看 询盘CAS: 111786-07-3
产地: 上海
规格: P910818
价格: 1mg-4680
库存: 7天内发货
电话: 13816333479/17821173903
手机: 13816333479/17821173903
电子邮件: wangrui@macklin.cn
QQ: 2885703204/288570320
微信: 19863730987/17821173903
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